Artificial electron carriers for photoenzymatic synthesis under visible light

Chemistry. 2012 Apr 27;18(18):5490-5. doi: 10.1002/chem.201200281. Epub 2012 Apr 4.

Abstract

NAD analogues can be employed as artificial electron carriers for photoenzymatic synthesis under visible light. Four different NAD analogues that have a 3-substituted pyridine ring have been investigated. 3-Acetylpyridine adenine dinucleotide and 3-pyridinealdehyde adenine dinucleotide were photochemically reduced much more efficiently than NAD, while their reduced products showed coenzyme activity comparable to natural NAD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coenzymes / chemistry
  • Coenzymes / metabolism
  • Electrons*
  • Light
  • NAD / analogs & derivatives*
  • NAD / chemistry
  • NAD / metabolism
  • Oxidation-Reduction

Substances

  • Coenzymes
  • NAD
  • 3-pyridinealdehyde-NAD
  • 3-acetylpyridine adenine dinucleotide