Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

Wei-Dong Xie; Xiu-Ru Wang; Li-Sha Ma; Xia Li; Kyung-Ho Row

doi:10.1016/j.fitote.2012.04.016

Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

Fitoterapia. 2012 Dec;83(8):1351-5. doi: 10.1016/j.fitote.2012.04.016. Epub 2012 Apr 28.

Authors

Wei-Dong Xie¹, Xiu-Ru Wang, Li-Sha Ma, Xia Li, Kyung-Ho Row

Affiliation

¹ Marine College, Shandong University, Weihai 264209, PR China. wdxie@sdu.edu.cn

PMID: 22561912
DOI: 10.1016/j.fitote.2012.04.016

Abstract

In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asteraceae / chemistry*
Cell Line, Tumor
Humans
Models, Molecular
Molecular Structure
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology*

Substances

Sesquiterpenes