Astroglial excitability is largely mediated by fluctuations in intracellular ion concentrations. In addition to generally acknowledged Ca²⁺ excitability of astroglia, recent studies have demonstrated that neuronal activity triggers transient increases in the cytosolic Na⁺ concentration ([Na⁺](i)) in perisynaptic astrocytes. These [Na⁺](i) transients are controlled by multiple Na⁺-permeable channels and Na⁺-dependent transporters; spatiotemporally organized [Na⁺](i) dynamics in turn regulate diverse astroglial homeostatic responses such as metabolic/signaling utilization of lactate and glutamate, transmembrane transport of neurotransmitters and K⁺ buffering. In particular, near-membrane [Na⁺](i) transients determine the rate and the direction of the transmembrane transport of GABA and Ca²⁺. We discuss here the role of Na⁺ in the regulation of various systems that mediate fast bidirectional communication between neurones and glia at the single synapse level.
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