Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5272-8. doi: 10.1016/j.bmcl.2012.06.055. Epub 2012 Jun 29.

Abstract

An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotoxic activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Inflammatory Agents / chemical synthesis*
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Inflammatory Agents / toxicity
  • Cell Proliferation / drug effects
  • Crystallography, X-Ray
  • Edema / chemically induced
  • Edema / drug therapy
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Humans
  • MCF-7 Cells
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Pyrazoles / chemistry*
  • Pyrazoles / therapeutic use
  • Pyrazoles / toxicity
  • Rats

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Pyrazoles