Abstract
An ecofriendly green approach for synthesis of substituted pyrano[2,3-c]pyrazoles has been developed via a multicomponent one pot approach in aqueous ethanol medium under totally non-catalytic conditions. The synthesized compounds were evaluated for their antibacterial, anti-inflammatory and cytotoxic activities.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / therapeutic use
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Anti-Inflammatory Agents / toxicity
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Edema / chemically induced
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Edema / drug therapy
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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MCF-7 Cells
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Microbial Sensitivity Tests
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Molecular Conformation
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Pyrazoles / chemistry*
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Pyrazoles / therapeutic use
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Pyrazoles / toxicity
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Rats
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Pyrazoles