Abstract
The CeO2 sol with the size of nanoparticles 2-4 nm has been synthesized. It has been determined that the synthesized nanocrystalline cerium has antibacterial activity in vitro against different groups of opportunistic microorganisms: clinical strains of Escherichia coli, Staphylococcus aureus and Candida albicans. The rate of viability depression of test-cultures depends on the concentration of cerium dioxide nanoparticles and time of incubation. It is shown that the sol interacts with the bacterial cell surface. It is suggested that the observed differences of antibacterial action of nanocrystalline cerium dioxide can be related to the structural characteristics of the cell surface.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Candida albicans / drug effects*
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Candida albicans / growth & development
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Cerium / chemistry
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Cerium / pharmacology*
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Colloids / chemical synthesis
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Colloids / pharmacology
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects*
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Escherichia coli / growth & development
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Humans
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Microbial Sensitivity Tests
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Microbial Viability / drug effects
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Microscopy, Electron
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Nanoparticles / chemistry
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Nanoparticles / ultrastructure*
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Opportunistic Infections / microbiology
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Particle Size
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
Substances
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Anti-Bacterial Agents
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Colloids
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Cerium
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ceric oxide