The role of hyaluronan in wound healing

Int Wound J. 2014 Apr;11(2):159-63. doi: 10.1111/j.1742-481X.2012.01057.x. Epub 2012 Aug 14.

Abstract

The polysaccharide hyaluronan (HA) (synonyms - hyaluronic acid, hyaluronate) is a versatile, polymorphic, glycosoaminoglycan with vast biological functions. HA is found throughout the body, primarily residing in skin, thus playing an important role in wound healing. Research regarding HA's function has changed over the years, primarily focussing on a particular aspect or function. The contribution of HA in each stage of normal wound healing as well as its clinical wound dressing applications will be examined.

Keywords: Hyaluronan; Clinical application; Dermatology; Wound healing; Wound dressings.

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Adjuvants, Immunologic / physiology*
  • Dermis / cytology
  • Epidermal Cells
  • Granulation Tissue / physiology
  • Humans
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / physiology*
  • Inflammation / physiopathology
  • Re-Epithelialization / physiology*
  • Wound Healing / physiology*

Substances

  • Adjuvants, Immunologic
  • Hyaluronic Acid