Abstract
A new aflatoxin, aflatoxin B(2b) (1), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes, with MIC values of 22.5, 1.7 and 1.1 M, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC(50) values of 8.1, 2.0 and 4.2 M, respectively. The results showed that hydration and hydrogenation of (8)-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aflatoxins / administration & dosage
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Aflatoxins / isolation & purification
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Aflatoxins / pharmacology*
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Aspergillus flavus / chemistry*
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Aspergillus flavus / isolation & purification
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Bacillus subtilis / drug effects
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Cell Line, Tumor
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Enterobacter aerogenes / drug effects
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Escherichia coli / drug effects
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Hibiscus / microbiology*
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Humans
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Inhibitory Concentration 50
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K562 Cells
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Microbial Sensitivity Tests
Substances
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Aflatoxins
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Anti-Infective Agents
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Antineoplastic Agents