Abstract
Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host. Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines. We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents / immunology*
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Anti-Inflammatory Agents / metabolism
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Cytokines / immunology*
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Cytokines / metabolism
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Humans
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Inflammation / immunology*
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Inflammation Mediators / immunology
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Inflammation Mediators / metabolism
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Interleukin-1 / immunology
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Interleukin-10 / immunology
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Interleukin-17 / immunology
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Interleukin-17 / metabolism
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Interleukin-2 / immunology
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Interleukins / immunology*
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Interleukins / metabolism
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Mice
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
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Transforming Growth Factor beta / immunology
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Transforming Growth Factor beta / metabolism
Substances
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Anti-Inflammatory Agents
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Cytokines
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IL37 protein, human
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Inflammation Mediators
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Interleukin-1
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Interleukin-17
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Interleukin-2
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Interleukins
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Transforming Growth Factor beta
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interleukin-35, human
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Interleukin-10