Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release

Lei Xing; Haoquan Zheng; Yuanyuan Cao; Shunai Che

doi:10.1002/adma.201201742

Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release

Adv Mater. 2012 Dec 18;24(48):6433-7. doi: 10.1002/adma.201201742. Epub 2012 Sep 24.

Authors

Lei Xing¹, Haoquan Zheng, Yuanyuan Cao, Shunai Che

Affiliation

¹ School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

PMID: 23001882
DOI: 10.1002/adma.201201742

Abstract

Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H(+) stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems*
Hydrogen-Ion Concentration
Nanoparticles / chemistry*
Particle Size
Polymers / chemical synthesis
Polymers / chemistry*
Porosity
Silicon Dioxide / chemistry*
Surface Properties
Topotecan / chemistry*

Substances

Polymers
Silicon Dioxide
Topotecan