Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry

Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11073-8. doi: 10.1002/anie.201206281. Epub 2012 Oct 4.

Abstract

It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Azides / chemistry*
  • Click Chemistry
  • DNA / chemistry*
  • Fibroblasts / cytology
  • G-Quadruplexes*
  • Humans
  • Microscopy, Fluorescence
  • Molecular Structure
  • RNA / chemistry*
  • Telomere / chemistry

Substances

  • Alkynes
  • Azides
  • RNA
  • DNA