Abstract
Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alginates / chemistry*
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Animals
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Biocompatible Materials / chemical synthesis
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Capsules / chemical synthesis*
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Cell Culture Techniques / instrumentation
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Cell Culture Techniques / methods
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Cells, Cultured
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / pathology
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Diabetes Mellitus, Experimental / surgery*
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Glucuronic Acid / chemistry
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Hexuronic Acids / chemistry
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Hydrogels / administration & dosage*
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Hydrogels / chemical synthesis*
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Islets of Langerhans Transplantation / methods*
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Male
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Mice
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Mice, Inbred C57BL
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Porosity
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Streptozocin
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Tissue Scaffolds*
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Treatment Outcome
Substances
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Alginates
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Biocompatible Materials
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Capsules
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Hexuronic Acids
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Hydrogels
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Streptozocin
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Glucuronic Acid