Treatment of acute and chronic focal neuropathic pain in cancer patients with lidocaine 5 % patches. A radiation and oncology department experience

Support Care Cancer. 2013 May;21(5):1329-34. doi: 10.1007/s00520-012-1670-x. Epub 2012 Dec 15.

Abstract

Purpose: This study aims to evaluate the utility of a new technology, Lidocaine 5 % patch (L5%P), for providing analgesia without other sensory deficit in cancer patients with focal neuropathic pain (NP) related or not with cancer.

Methods: During the period February 2011 to July 2011, 83 patients were seen for the first time in our department and L5%P were prescribed to 15 of those patients (18.07 %). Information recorded in relation to the L5%P included the following: (a) Nature of NP, (b) medications tested, (c) drug combinations, (d) L5%P therapy duration, (e) efficacy, and (f) undesirable effects.

Results: Forty percent of the patients (n = 6) in our series had NP related to their cancer and 60 % (n = 9), chronic NP not related to their cancer diagnosis, but all referred to our Radiotherapy and Oncology Department for radiotherapy. The analgesic effect of the L5%P was potent in eight cases (53.33 %) and partial in four cases (26.66 %). This represents 79.99 % efficacy in selected patients. There were no serious adverse events reported in any of the patients.

Conclusion: The results indicate that there are patients with NP within a cancer setting who are suitable for treatment and successfully managed with topical L5%P, alone or in combination with other drugs.

MeSH terms

  • Acute Pain / drug therapy
  • Acute Pain / etiology
  • Aged
  • Aged, 80 and over
  • Anesthetics, Local / administration & dosage
  • Anesthetics, Local / adverse effects
  • Anesthetics, Local / therapeutic use*
  • Chronic Pain / drug therapy
  • Chronic Pain / etiology
  • Female
  • Humans
  • Lidocaine / administration & dosage
  • Lidocaine / adverse effects
  • Lidocaine / therapeutic use*
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Neoplasms / radiotherapy
  • Neuralgia / drug therapy*
  • Neuralgia / etiology
  • Retrospective Studies
  • Transdermal Patch
  • Treatment Outcome

Substances

  • Anesthetics, Local
  • Lidocaine