Abstract
To investigate whether capsaicin and menthol stimuli elicit characteristic responses in facial skin blood flow (SkBF), we observed the facial SkBF response to low and high concentrations of capsaicin and menthol stimuli of 1-ml solution applied to the oral cavity for 20s in 17 healthy subjects. High concentration of capsaicin significantly increased the SkBF in all of the facial areas monitored. High concentration of menthol stimulus significantly decreased SkBF in the nose and increased that in the eyelid, and upper and lower lips. These results demonstrated that capsaicin and menthol stimuli in the oral cavity elicit characteristic responses in facial SkBF.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Capsaicin / administration & dosage
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Capsaicin / adverse effects
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Capsaicin / pharmacology*
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Dose-Response Relationship, Drug
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Face / blood supply*
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Female
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Flavoring Agents / administration & dosage
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Flavoring Agents / adverse effects
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Flavoring Agents / pharmacology
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Humans
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Irritants / administration & dosage
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Irritants / adverse effects
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Irritants / pharmacology*
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Japan
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Kinetics
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Male
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Menthol / administration & dosage
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Menthol / adverse effects
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Menthol / pharmacology*
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Mouth Mucosa / blood supply
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Mouth Mucosa / drug effects*
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Pain Measurement
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Regional Blood Flow / drug effects*
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Sensory System Agents / administration & dosage
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Sensory System Agents / adverse effects
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Sensory System Agents / pharmacology
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Skin / blood supply*
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Young Adult
Substances
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Flavoring Agents
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Irritants
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Sensory System Agents
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Menthol
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Capsaicin