Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method

Fitoterapia. 2013 Mar:85:8-13. doi: 10.1016/j.fitote.2012.12.029. Epub 2013 Jan 10.

Abstract

Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. TCA 1b (5) showed weak activity against the Bacille Calmette-Guerin strain with the MIC of 125μg/mL. TCA 9b (10) exhibited strong cytotoxic activity against Hela cell line with IC50 of 8.58μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / isolation & purification*
  • Antineoplastic Agents / isolation & purification*
  • Ascomycota / chemistry*
  • Culture Techniques
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Lichens / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Diterpenes