Abstract
This chapter will review the proteome alterations induced by ionizing radiation in cellular systems or using animal models with whole body or localised exposure. The recent developments in qualitative and quantitative proteome analysis using formalin-fixed paraffin-embedded material from radiobiology archives will be illustrated. The development of promising protein targets to be used as radiation biomarkers in future molecular epidemiology studies is described.
MeSH terms
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Biological Specimen Banks
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Cardiovascular System / metabolism
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Cardiovascular System / radiation effects*
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Endothelial Cells / radiation effects*
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Endothelium, Vascular / metabolism
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Endothelium, Vascular / pathology
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Endothelium, Vascular / radiation effects*
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Formaldehyde
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Heart / radiation effects
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Humans
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Lymphocytes / metabolism
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Lymphocytes / pathology
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Lymphocytes / radiation effects*
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Mitochondria / metabolism
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Mitochondria / pathology
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Mitochondria / radiation effects*
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Paraffin Embedding
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Protein Interaction Mapping
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Proteome / metabolism*
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Radiation, Ionizing
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Tissue Fixation