Hydrophobic end-gated silica nanotubes for intracellular glutathione-stimulated drug delivery in drug-resistant cancer cells

Chem Commun (Camb). 2013 Apr 21;49(31):3194-6. doi: 10.1039/c3cc38761e. Epub 2013 Feb 15.

Authors

Lulu Wang¹, Mira Kim, Qiling Fang, Junhong Min, Won Il Jeon, So Yeong Lee, Sang Jun Son, Sang-Woo Joo, Sang Bok Lee

Affiliation

¹ Department of Chemistry, Gachon University, Seongnam, 461-701, Korea.

PMID: 23417143
DOI: 10.1039/c3cc38761e

Abstract

Intracellular glutathione-triggered doxorubicin release from silica nanotubes with hydrophobic labile cap was demonstrated for the drug-resistant cancer cell treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibiotics, Antineoplastic / administration & dosage
Antibiotics, Antineoplastic / toxicity
Cell Line, Tumor
Cell Survival / drug effects
Doxorubicin / administration & dosage
Doxorubicin / toxicity
Drug Carriers / chemistry*
Drug Resistance, Neoplasm
Glutathione / chemistry
Glutathione / metabolism*
Humans
Hydrophobic and Hydrophilic Interactions
MCF-7 Cells
Mice
Mice, Nude
Nanotubes / chemistry*
Neoplasms / drug therapy
Silicon Dioxide / chemistry*
Transplantation, Heterologous

Substances

Antibiotics, Antineoplastic
Drug Carriers
Silicon Dioxide
Doxorubicin
Glutathione