A case-control association study between Obsessive-Compulsive Disorder (OCD) and the MCP-1 -2518G/A polymorphism in a Chinese sample

Braz J Psychiatry. 2012 Dec;34(4):451-3. doi: 10.1016/j.rbp.2012.01.002.

Abstract

Objective: To investigate the association between Obsessive-Compulsive Disorder (OCD) and a functional polymorphism of MCP-1 in the Chinese Han population.

Method: We genotyped and performed a case-control association analysis of the MCP-1 -2518G/A polymorphism in 200 OCD patients and 294 healthy control subjects.

Results: There was no significant difference in MCP-1 -2518G/A genotypic and allelic frequencies between OCD cases and controls (x² = 1.123, df = 2, P = 0.57 by genotype; x² = 0.802, df = 1, P = 0.37 by allele).

Conclusions: Our results indicated that MCP-1 -2518G/A may not play a major role in the genetic predisposition of the Chinese Han population to OCD. However, further studies using a larger number of subjects are required to obtain a clear conclusion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Asian People / genetics
  • Case-Control Studies
  • Chemokine CCL2 / genetics*
  • China
  • Female
  • Gene Frequency
  • Genetic Association Studies / methods*
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Risk Factors

Substances

  • CCL2 protein, human
  • Chemokine CCL2