Abstract
We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4+ and CD8+ T-cells, and a skewed T-cell phenotype from naive toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify patients with higher immunoactivation despite ART.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Aging / immunology
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Anti-HIV Agents / therapeutic use*
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Antiretroviral Therapy, Highly Active / methods
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Biomarkers*
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CD4-CD8 Ratio
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Cellular Senescence / immunology*
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Child
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HIV Infections / drug therapy*
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HIV Infections / immunology
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HIV Infections / transmission
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Humans
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Infectious Disease Transmission, Vertical
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Lymphocyte Activation / immunology*
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Regression Analysis
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Viral Load / immunology
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Young Adult
Substances
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Anti-HIV Agents
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Biomarkers