hERG channel function: beyond long QT

Acta Pharmacol Sin. 2013 Mar;34(3):329-35. doi: 10.1038/aps.2013.6.

Abstract

To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • ERG1 Potassium Channel
  • Ether-A-Go-Go Potassium Channels / biosynthesis
  • Ether-A-Go-Go Potassium Channels / genetics
  • Ether-A-Go-Go Potassium Channels / physiology*
  • Gene Expression*
  • Humans
  • Long QT Syndrome / genetics
  • Long QT Syndrome / metabolism*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Organ Specificity

Substances

  • ERG1 Potassium Channel
  • Ether-A-Go-Go Potassium Channels
  • KCNH2 protein, human