Abstract
To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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ERG1 Potassium Channel
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Ether-A-Go-Go Potassium Channels / biosynthesis
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Ether-A-Go-Go Potassium Channels / genetics
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Ether-A-Go-Go Potassium Channels / physiology*
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Gene Expression*
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Humans
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Long QT Syndrome / genetics
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Long QT Syndrome / metabolism*
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Neoplasms / genetics
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Neoplasms / metabolism*
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Organ Specificity
Substances
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ERG1 Potassium Channel
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Ether-A-Go-Go Potassium Channels
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KCNH2 protein, human