Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng

Qinge Ma; Jin Tian; Jianbo Yang; Aiguo Wang; Tengfei Ji; Yangai Wang; Yalun Su

doi:10.1016/j.fitote.2013.03.003

Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng

Fitoterapia. 2013 Jun:87:1-6. doi: 10.1016/j.fitote.2013.03.003. Epub 2013 Mar 14.

Authors

Qinge Ma¹, Jin Tian, Jianbo Yang, Aiguo Wang, Tengfei Ji, Yangai Wang, Yalun Su

Affiliation

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. maqinge2010@163.com

PMID: 23500386
DOI: 10.1016/j.fitote.2013.03.003

Abstract

Four new carbazole alkaloids (1-4) and fourteen known carbazole alkaloids (5-18) were isolated from Murraya koenigii. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 4, 6, 16, and 17 (10 μM) had moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage. Compounds 11, 12 and 18 showed significant PTP1B inhibitory activity with IC50 values of 1.773, 1.875 and 2.286 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Carbazoles / chemistry
Carbazoles / isolation & purification
Carbazoles / pharmacology*
Cell Line
Chemical and Drug Induced Liver Injury / prevention & control
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology
Galactosamine
Humans
Inhibitory Concentration 50
Liver / drug effects*
Molecular Structure
Murraya / chemistry*
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*

Substances

Alkaloids
Carbazoles
Enzyme Inhibitors
Plant Extracts
Galactosamine
Protein Tyrosine Phosphatase, Non-Receptor Type 1