Abstract
A practical one-pot and regiospecific three-component process for the synthesis of 2,3-disubstituted indoles from 2-bromoanilides was developed via consecutive palladium-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
MeSH terms
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Amides / chemistry*
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Anilides / chemistry*
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Catalysis
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Cyclization
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Hydrocarbons, Brominated / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry
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Molecular Structure
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Organometallic Compounds / chemistry
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Oxidation-Reduction
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Palladium / chemistry*
Substances
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Amides
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Anilides
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Hydrocarbons, Brominated
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Indoles
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Organometallic Compounds
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Palladium