Abstract
Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Drug Evaluation, Preclinical
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology*
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Fruit / chemistry*
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Gene Expression / genetics
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Glutathione Peroxidase / metabolism
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Hydrogen Bonding
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Hyperlipidemias / drug therapy
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / isolation & purification
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Hypolipidemic Agents / pharmacology*
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Lipid Metabolism / drug effects
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Lipid Metabolism / genetics
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Lipoprotein Lipase / genetics
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Lipoprotein Lipase / metabolism
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Liver / drug effects
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Liver / metabolism
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Liver / pathology
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Lovastatin / pharmacology
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Male
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Malondialdehyde / metabolism
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Molecular Weight
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PPAR gamma / genetics
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PPAR gamma / metabolism
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Polysaccharides / chemistry
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Polysaccharides / isolation & purification
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Polysaccharides / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Rosaceae / chemistry*
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Superoxide Dismutase / metabolism
Substances
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Antioxidants
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Drugs, Chinese Herbal
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Hypolipidemic Agents
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PPAR gamma
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Polysaccharides
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Malondialdehyde
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Lovastatin
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Glutathione Peroxidase
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Superoxide Dismutase
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Lipoprotein Lipase