Hypolipidemic and antioxidant activities of polysaccharides from Rosae Laevigatae Fructus in rats

Carbohydr Polym. 2013 Apr 15;94(1):56-62. doi: 10.1016/j.carbpol.2013.01.006. Epub 2013 Jan 11.

Abstract

Two major fractions (RLP-1 and RLP-2) were obtained by purifying the crude polysaccharides extracted from a traditional Chinese herb Rosae Laevigatae Fructus. The average molecular weight of RLP-1 and RLP-2 was 21.5 kDa and 16.1 kDa, respectively. Monosaccharide analysis indicated that RLP-1 was composed of xylose, mannose and galactose in the molar ratio of 1:11:8, while RLP-2 was only a glucan. Oral administration of RLP-1 could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), inhibit hepatic lipid accumulation, increase antioxidant lipids and up-regulate expressions of peroxisome proliferator-activated receptor-γ (PPAR-γ) and lipoprotein lipase (LPL) in hyperlipidemia rats. These results suggest that RLP-1 improve hyperlipidemia possibly through regulating PPAR-mediated lipid metabolism. Therefore, could be explored as a possible agent for hyperlipidemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Drug Evaluation, Preclinical
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology*
  • Fruit / chemistry*
  • Gene Expression / genetics
  • Glutathione Peroxidase / metabolism
  • Hydrogen Bonding
  • Hyperlipidemias / drug therapy
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / isolation & purification
  • Hypolipidemic Agents / pharmacology*
  • Lipid Metabolism / drug effects
  • Lipid Metabolism / genetics
  • Lipoprotein Lipase / genetics
  • Lipoprotein Lipase / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Liver / pathology
  • Lovastatin / pharmacology
  • Male
  • Malondialdehyde / metabolism
  • Molecular Weight
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • Polysaccharides / chemistry
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Rosaceae / chemistry*
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Drugs, Chinese Herbal
  • Hypolipidemic Agents
  • PPAR gamma
  • Polysaccharides
  • Malondialdehyde
  • Lovastatin
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Lipoprotein Lipase