To be immunogenic, or not to be: that's the iPSC question

Shin Kaneko; Shinya Yamanaka

doi:10.1016/j.stem.2013.03.008

To be immunogenic, or not to be: that's the iPSC question

Cell Stem Cell. 2013 Apr 4;12(4):385-6. doi: 10.1016/j.stem.2013.03.008.

Authors

Shin Kaneko¹, Shinya Yamanaka

Affiliation

¹ Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan. kaneko.shin@cira.kyoto-u.ac.jp

PMID: 23561437
DOI: 10.1016/j.stem.2013.03.008

Abstract

The unexpected finding that autologous induced pluripotent stem cell (iPSC)-derived teratomas are immunogenic in syngeneic hosts sparked pessimism over their therapeutic potential; however, two recent reports (Guha et al., 2013 and Araki et al., 2013; the latter in this issue of Cell stem cell) contradict previous findings, showing no immunogenicity of in vitro differentiated syngeneic iPS-derived cells and supporting their safety.

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