New evidence about an old drug--risk with codeine after adenotonsillectomy

N Engl J Med. 2013 Jun 6;368(23):2155-7. doi: 10.1056/NEJMp1302454. Epub 2013 Apr 24.
No abstract available

MeSH terms

  • Adenoidectomy*
  • Child
  • Child, Preschool
  • Codeine / adverse effects*
  • Codeine / metabolism
  • Contraindications
  • Cytochrome P-450 CYP2D6 / genetics
  • Cytochrome P-450 CYP2D6 / metabolism
  • Drug Therapy / mortality
  • Humans
  • Morphine / metabolism
  • Pain, Postoperative / drug therapy
  • Respiratory Insufficiency / chemically induced
  • Tonsillectomy*

Substances

  • Morphine
  • Cytochrome P-450 CYP2D6
  • Codeine