DNA hypermethylation leads to lower FOXP3 expression in CD4+ T cells of patients with primary Sjögren's syndrome

Clin Immunol. 2013 Aug;148(2):254-7. doi: 10.1016/j.clim.2013.05.005. Epub 2013 May 22.
No abstract available

Keywords: CD4(+) T cells; DNA methylation; FOXP3; Primary Sjögren's syndrome.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • CD4-Positive T-Lymphocytes / metabolism*
  • DNA Methylation*
  • Female
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism*
  • Gene Expression Regulation / physiology
  • Humans
  • Male
  • Middle Aged
  • Sjogren's Syndrome / genetics*
  • Sjogren's Syndrome / metabolism*
  • Young Adult

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors