A randomized trial evaluating the effects of change in dairy food consumption on cardio-metabolic risk factors

Eur J Prev Cardiol. 2014 Nov;21(11):1376-86. doi: 10.1177/2047487313493567. Epub 2013 Jun 17.

Abstract

Background: It is currently not known whether dairy food influences the risk of cardiovascular disease or diabetes. This study evaluates effects of changing dairy intake on cardio-metabolic risk factors.

Methods: 180 healthy volunteers were randomised to increase, reduce or not change their dairy intake for 1 month in response to dietary advice. Body weight, waist circumference, blood pressure, fasting plasma lipids, insulin resistance and C-reactive protein (CRP) were measured at baseline and after 1 month and compared by dietary group.

Results: 176 (98%) subjects completed the study. Average change in self-reported dairy fat intake for increased dairy food was +0.9 SD 1.1 g/day (+71%), no change was -2.1 SD 0.4 g/day (-15%) and decreased dairy food was -10.8 SD 1.2 g/day (-77%) respectively. There was no statistically significant change in LDL or HDL cholesterol, triglycerides, systolic or diastolic blood pressure, C-reactive protein, glucose or insulin with 95% CI standard mean differences <0.2 for all and CRP <0.3. There was a small increase in weight (+0.4 kg, SD 3.1) in those asked to increase dairy food.

Conclusions: In healthy volunteers, dietary advice to change dairy intake for 1 month did not have a clinically significant effect on cardio-metabolic risk factors. These observations suggest that dairy food can be included as part of a normal healthy diet without increasing cardio-metabolic risk.

Trial registration number: ACTRN12612000574842.

Keywords: Dairy; blood pressure; cardio-metabolic risk factors; dietary intervention; insulin resistance; lipids; weight.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Blood Pressure
  • Body Weight
  • C-Reactive Protein / metabolism
  • Dairy Products* / adverse effects
  • Diet* / adverse effects
  • Feeding Behavior
  • Female
  • Health Behavior
  • Health Status
  • Healthy Volunteers
  • Humans
  • Inflammation Mediators / blood
  • Insulin Resistance
  • Lipids / blood
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / diagnosis
  • Metabolic Syndrome / etiology
  • Metabolic Syndrome / physiopathology
  • Metabolic Syndrome / prevention & control*
  • Middle Aged
  • New Zealand
  • Risk Factors
  • Time Factors
  • Waist Circumference

Substances

  • Biomarkers
  • Inflammation Mediators
  • Lipids
  • C-Reactive Protein

Associated data

  • ANZCTR/12612000574842