PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

Junjie Li; Zhishen Ge; Shiyong Liu

doi:10.1039/c3cc43576h

PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

Chem Commun (Camb). 2013 Aug 11;49(62):6974-6. doi: 10.1039/c3cc43576h.

Authors

Junjie Li¹, Zhishen Ge, Shiyong Liu

Affiliation

¹ CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR China.

PMID: 23802223
DOI: 10.1039/c3cc43576h

Abstract

A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Transfer Techniques
Genetic Vectors / chemistry
Genetic Vectors / metabolism*
Matrix Metalloproteinases / chemistry
Matrix Metalloproteinases / metabolism*
Micelles
Peptides / chemistry
Peptides / metabolism*
Polyethylene Glycols / chemistry
Polyethylene Glycols / metabolism*

Substances

Micelles
Peptides
Polyethylene Glycols
Matrix Metalloproteinases