Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism

Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8620-4. doi: 10.1002/anie.201303999. Epub 2013 Jul 3.
No abstract available

Keywords: biological activity; drug delivery; drug design; kinetics; proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain
  • Crystallography, X-Ray
  • Drug Delivery Systems*
  • Enzyme Inhibitors / pharmacology*
  • Flavin-Adenine Dinucleotide / metabolism
  • Histone Demethylases / antagonists & inhibitors*
  • Histone Demethylases / chemistry
  • Humans
  • Lysine / chemistry*
  • Lysine / metabolism
  • Molecular Structure
  • Monoamine Oxidase / chemistry
  • Monoamine Oxidase / metabolism
  • Monoamine Oxidase Inhibitors / pharmacology
  • Peptide Fragments / pharmacology*
  • Small Molecule Libraries
  • Tranylcypromine / pharmacology*

Substances

  • Enzyme Inhibitors
  • Monoamine Oxidase Inhibitors
  • Peptide Fragments
  • Small Molecule Libraries
  • Flavin-Adenine Dinucleotide
  • Tranylcypromine
  • Histone Demethylases
  • Monoamine Oxidase
  • KDM1A protein, human
  • Lysine