Abstract
A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / metabolism*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cell Line
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Cyclooxygenase 2 / drug effects
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Inflammation / chemically induced
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Inflammation / drug therapy*
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Lipopolysaccharides
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Macrophages / drug effects
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Macrophages / immunology
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Mice
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Nitric Oxide Synthase Type II / drug effects
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Quinones / chemistry
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Quinones / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lipopolysaccharides
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Quinones
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flexibilisquinone
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Nitric Oxide Synthase Type II
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Cyclooxygenase 2