Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study

Neurobiol Aging. 2013 Dec;34(12):2889.e11-3. doi: 10.1016/j.neurobiolaging.2013.06.004. Epub 2013 Jul 12.

Abstract

Recent studies have identified the rs75932628 (R47H) variant in TREM2 as an Alzheimer's disease risk factor with estimated odds ratio ranging from 2.9 to 5.1. The Cache County Memory Study is a large, population-based sample designed for the study of memory and aging. We genotyped R47H in 2974 samples (427 cases and 2540 control subjects) from the Cache County study using a custom TaqMan assay. We observed 7 heterozygous cases and 12 heterozygous control subjects with an odds ratio of 3.5 (95% confidence interval, 1.3-8.8; p = 0.0076). The minor allele frequency and population attributable fraction for R47H were 0.0029 and 0.004, respectively. This study replicates the association between R47H and Alzheimer's disease risk in a large, population-based sample, and estimates the population frequency and attributable risk of this rare variant.

Keywords: Alzheimer's disease; Human; R47H; Rare variant; TREM2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • Gene Frequency
  • Genetic Variation / genetics*
  • Genetics, Population / methods*
  • Genotype
  • Heterozygote
  • Humans
  • Membrane Glycoproteins / genetics*
  • Receptors, Immunologic / genetics*
  • Risk Factors
  • Sample Size
  • Utah

Substances

  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM2 protein, human