Predominantly proinflammatory cytokines decrease after B cell depletion therapy in patients with primary Sjogren's syndrome

Ann Rheum Dis. 2013 Dec;72(12):2048-50. doi: 10.1136/annrheumdis-2013-203447. Epub 2013 Jul 17.

Authors

R P E Pollard¹, W H Abdulahad, H Bootsma, P M Meiners, F K L Spijkervet, M G Huitema, J G M Burgerhof, A Vissink, F G M Kroese

Affiliation

¹ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, , Groningen, The Netherlands.

PMID: 23864239
DOI: 10.1136/annrheumdis-2013-203447

No abstract available

Keywords: B cells; Chemokines; Cytokines; Sjögren's Syndrome; Treatment.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal, Murine-Derived / therapeutic use*
B-Lymphocytes / immunology
Cytokines / blood*
Female
Humans
Immunologic Factors / therapeutic use*
Inflammation Mediators / metabolism*
Lymphocyte Depletion
Male
Rituximab
Sjogren's Syndrome / drug therapy*

Substances

Antibodies, Monoclonal, Murine-Derived
Cytokines
Immunologic Factors
Inflammation Mediators
Rituximab