Synthesis of ZnO nanoparticles and evaluation of antioxidant and cytotoxic activity

Colloids Surf B Biointerfaces. 2013 Nov 1:111:556-60. doi: 10.1016/j.colsurfb.2013.06.041. Epub 2013 Jul 5.

Abstract

ZnO nanoparticles were synthesized by thermal decomposition method and were characterized by UV-vis spectroscopy, XRD, SEM, EDX and TEM analysis. The resultant nanoparticles are nearly spherical and size is in the range of 40-50 nm. The antioxidant behavior of ZnO nanoparticles was assessed by scavenging free radicals of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) with varying nanoparticle concentration and time interval individually. The DPPH scavenging activity was monitored by UV-vis spectrophotometer. ZnO nanoparticles were also showing cytotoxic activity which was studied by hemolytic potentiality test.

Keywords: Antioxidant; Cytotoxic; DPPH; Nanoparticle; ZnO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Cell Death / drug effects
  • Hemolysis / drug effects
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Sheep
  • Spectrometry, X-Ray Emission
  • Spectrophotometry, Ultraviolet
  • Time Factors
  • X-Ray Diffraction
  • Zinc Oxide / chemical synthesis*
  • Zinc Oxide / pharmacology*

Substances

  • Antioxidants
  • Zinc Oxide