Phosphoramidate synthesis via copper-catalysed aerobic oxidative coupling of amines and H-phosphonates

Chem Commun (Camb). 2013 Oct 11;49(79):8919-21. doi: 10.1039/c3cc45680c.

Abstract

The copper-catalysed oxidative coupling of amines and H-phosphonates to produce phosphoramidates has been achieved using CuI as the catalyst and O2 (present in air) as the sole oxidant.

MeSH terms

  • Amides / chemical synthesis
  • Amides / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Organophosphonates / chemistry*
  • Oxidative Coupling
  • Oxygen / chemistry
  • Phosphoric Acids / chemical synthesis
  • Phosphoric Acids / chemistry*

Substances

  • Amides
  • Amines
  • Organophosphonates
  • Phosphoric Acids
  • Copper
  • phosphoramidic acid
  • Oxygen