Pediatric Risk Factors for Candidemia Secondary to Candida glabrata and Candida krusei Species

Priya A Prasad; Brian T Fisher; Susan E Coffin; Thomas J Walsh; Karin L McGowan; Robert Gross; Theoklis E Zaoutis

doi:10.1093/jpids/pis093

Pediatric Risk Factors for Candidemia Secondary to Candida glabrata and Candida krusei Species

J Pediatric Infect Dis Soc. 2013 Sep;2(3):263-6. doi: 10.1093/jpids/pis093. Epub 2012 Oct 30.

Authors

Priya A Prasad¹, Brian T Fisher², Susan E Coffin³, Thomas J Walsh⁴, Karin L McGowan⁵, Robert Gross⁶, Theoklis E Zaoutis²

Affiliations

¹ Division of Infectious Diseases prasad@email.chop.edu.
² Division of Infectious Diseases Center for Pediatric Clinical Effectiveness Department of Pediatrics, The Children's Hospital of Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine.
³ Division of Infectious Diseases Center for Pediatric Clinical Effectiveness Department of Pediatrics, The Children's Hospital of Philadelphia, Pennsylvania.
⁴ Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland Transplantation-Oncology Infectious Diseases Program, Weill Cornell University Medical Center, New York, New York.
⁵ Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania.
⁶ Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania.

Abstract

This 13-year retrospective study investigated risk factors for candidemia secondary to Candida species with increased likelihood of fluconazole resistance. Of 344 candidemia cases, 23 were caused by C glabrata or C krusei (CGCK). Age >2 years, recent fluconazole exposure, and recent surgery were independent risk factors for CGCK.

Keywords: Candidemia; fluconazole resistance; pediatrics; risk factors.