Abstract
Octaphlorethol A is a phenolic compound isolated from the marine alga Ishige foliacea. In the present study, we investigated the anti-inflammatory activity of octaphlorethol A in CpG-stimulated primary murine bone marrow-derived macrophages and dendritic cells. It exhibited anti-inflammatory activity by regulating the mitogen-activated protein kinase and NF-κB pathways.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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CpG Islands*
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HEK293 Cells
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Humans
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Inflammation / drug therapy
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Inflammation / genetics
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Inflammation / metabolism
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Mitogen-Activated Protein Kinases / metabolism*
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NF-kappa B / metabolism*
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Phenols / pharmacology*
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Phenols / therapeutic use
Substances
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Anti-Inflammatory Agents
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NF-kappa B
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Phenols
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octaphlorethol A
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Mitogen-Activated Protein Kinases