New and highly potent antitumor natural products from marine-derived fungi: covering the period from 2003 to 2012

Curr Top Med Chem. 2013;13(21):2745-66. doi: 10.2174/15680266113136660197.

Abstract

This review covers the 2003-2012 literature data published for antitumor natural products from marine-derived fungi. The focus is on new and highly potent cytotoxic compounds, together with details related to the relevant fungal species. It describes 22 promising bioactives, originating mainly from symbiotic fungi. The chemical structures of all highlighted organic molecules are briefly discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Aquatic Organisms
  • Biological Products / chemistry
  • Drug Screening Assays, Antitumor
  • Fungi / chemistry*
  • Humans
  • Indole Alkaloids / pharmacology
  • Molecular Structure

Substances

  • Antineoplastic Agents, Phytogenic
  • Biological Products
  • Indole Alkaloids
  • leptosin O