SH2B3: a new leukemia predisposition gene

Blood. 2013 Oct 3;122(14):2293-5. doi: 10.1182/blood-2013-08-519843.

Abstract

In this issue of Blood, Perez-Garcia et al report the important discovery of an inherited germline mutation in the gene encoding the SH2B adaptor protein 3 (SH2B3) in a consanguineous family affected with autoimmune disorders and acute lymphoblastic leukemia (ALL).

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Proteins / genetics*

Substances

  • Adaptor Proteins, Signal Transducing
  • Intracellular Signaling Peptides and Proteins
  • Proteins
  • SH2B3 protein, human