Abstract
In this issue of Blood, Perez-Garcia et al report the important discovery of an inherited germline mutation in the gene encoding the SH2B adaptor protein 3 (SH2B3) in a consanguineous family affected with autoimmune disorders and acute lymphoblastic leukemia (ALL).
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Female
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Humans
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Intracellular Signaling Peptides and Proteins
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Male
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Proteins / genetics*
Substances
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Adaptor Proteins, Signal Transducing
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Intracellular Signaling Peptides and Proteins
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Proteins
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SH2B3 protein, human