Nanoparticles containing insoluble drug for cancer therapy

Biotechnol Adv. 2014 Jul-Aug;32(4):778-88. doi: 10.1016/j.biotechadv.2013.10.002. Epub 2013 Oct 8.

Abstract

Nanoparticle drug formulations have been extensively researched and developed in the field of drug delivery as a means to efficiently deliver insoluble drugs to tumor cells. By mechanisms of the enhanced permeability and retention effect, nanoparticle drug formulations are capable of greatly enhancing the safety, pharmacokinetic profiles and bioavailability of the administered treatment. Here, the progress of various nanoparticle formulations in both research and clinical applications is detailed with a focus on the development of drug/gene delivery systems. Specifically, the unique advantages and disadvantages of polymeric nanoparticles, liposomes, solid lipid nanoparticles, nanocrystals and lipid-coated nanoparticles for targeted drug delivery will be investigated in detail.

Keywords: Calcium phosphate; Drug delivery; Gold nanoparticle; Lipid; Liposome; Nanocrystals; Nanoparticle; Polymer; siRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Drug Delivery Systems*
  • Gold / chemistry
  • Humans
  • Lipids / chemistry
  • Liposomes / chemistry*
  • Metal Nanoparticles / chemistry
  • Nanomedicine / methods*
  • Nanoparticles / chemistry*
  • Permeability
  • Polymers / chemistry
  • RNA, Small Interfering / chemistry*
  • RNA, Small Interfering / metabolism

Substances

  • Antineoplastic Agents
  • Lipids
  • Liposomes
  • Polymers
  • RNA, Small Interfering
  • Gold