Abstract
Chemical examination of the exuded gum resin of Boswellia carterii resulted in the isolation of nine new prenylaromadendrane-type diterpenes, boscartols A-I (1-9). The structures of these compounds were established by extensive 1D and 2D NMR spectroscopic analyses, mass spectrometric data, and circular dichroism spectra. Compounds 1-3, 5, 6, 8, and 9 (10 μM) showed moderate hepatoprotective activity against d-galactosamine-induced HL-7702 cell damage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boswellia / chemistry*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Galactosamine / pharmacology
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Gingiva / drug effects
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Humans
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Immunologic Factors
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Liver / drug effects*
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Liver / metabolism
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Resins, Plant / chemistry
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Resins, Plant / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Diterpenes
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Immunologic Factors
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Resins, Plant
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Triterpenes
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Galactosamine