Abstract
HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, N-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.
MeSH terms
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Cell Death / drug effects*
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Cell Death / genetics*
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Ethylmaleimide / toxicity*
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Gene Expression / genetics
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Gene Knockdown Techniques*
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HEK293 Cells
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / physiology*
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Humans
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Hydrogen Peroxide / toxicity*
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Oxidative Stress / drug effects*
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Oxidative Stress / genetics*
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Oxidative Stress / physiology
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Paraquat / toxicity*
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RNA, Double-Stranded
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RNA, Small Interfering
Substances
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HOXB13 protein, human
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Homeodomain Proteins
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RNA, Double-Stranded
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RNA, Small Interfering
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Hydrogen Peroxide
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Ethylmaleimide
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Paraquat