DSM-5 PTSD's symptom dimensions and relations with major depression's symptom dimensions in a primary care sample

Psychiatry Res. 2014 Jan 30;215(1):146-53. doi: 10.1016/j.psychres.2013.10.015. Epub 2013 Oct 23.

Abstract

Existing literature indicates significant comorbidity between posttraumatic stress disorder (PTSD) and major depression. We examined whether PTSD's dysphoria and mood/cognitions factors, conceptualized by the empirically supported four-factor DSM-5 PTSD models, account for PTSD's inherent relationship with depression. We hypothesized that depression's somatic and non-somatic factors would be more related to PTSD's dysphoria and mood/cognitions factors than other PTSD model factors. Further, we hypothesized that PTSD's arousal would significantly mediate relations between PTSD's dysphoria and somatic/non-somatic depression. Using 181 trauma-exposed primary care patients, confirmatory factor analyses (CFA) indicated a well-fitting DSM-5 PTSD dysphoria model, DSM-5 numbing model and two-factor depression model. Both somatic and non-somatic depression factors were more related to PTSD's dysphoria and mood/cognitions factors than to re-experiencing and avoidance factors; non-somatic depression was more related to PTSD's dysphoria than PTSD's arousal factor. PTSD's arousal did not mediate the relationship between PTSD's dysphoria and somatic/non-somatic depression. Implications are discussed.

Keywords: Confirmatory factor analyses; DSM-5; Depression; Mediation; PTSD; Primary care sample; Structural equation modeling.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arousal
  • Depressive Disorder, Major / complications
  • Depressive Disorder, Major / diagnosis*
  • Diagnostic and Statistical Manual of Mental Disorders*
  • Factor Analysis, Statistical
  • Female
  • Humans
  • Male
  • Middle Aged
  • Primary Health Care
  • Stress Disorders, Post-Traumatic / complications
  • Stress Disorders, Post-Traumatic / diagnosis*
  • Young Adult