Abstract
Over the last 10 years, progress has been made in understanding the relationship between hematopoietic stem cells and their microenvironment, or niche. Increased knowledge of the microenvironment and its effects on hematopoiesis and leukemogenesis based on murine models may lead to the identification of relevant new therapeutic targets for leukemia. In particular, the chemokine CCL3 has potential as a mediator of leukemia-induced microenvironmental changes, as it has been found to be increased in human acute myeloid leukemia.
Keywords:
CCL3; acute leukemia; hematopoietic stem cell; microenvironment; niche; targets.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Bone Marrow Cells / immunology
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Bone Marrow Cells / pathology
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Cell Differentiation
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Chemokine CCL3 / genetics*
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Chemokine CCL3 / immunology
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Disease Models, Animal
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Gene Expression Regulation, Leukemic*
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Hematopoiesis / immunology
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Hematopoietic Stem Cells / immunology*
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Hematopoietic Stem Cells / pathology
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Humans
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Myeloid, Acute / immunology
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Leukemia, Myeloid, Acute / pathology
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Mesenchymal Stem Cells / immunology
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Mesenchymal Stem Cells / pathology
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Mice
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Osteoblasts / immunology*
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Osteoblasts / pathology
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Stem Cell Niche / genetics
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Stem Cell Niche / immunology
Substances
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CCL3 protein, human
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Chemokine CCL3