Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. and their α-glucosidase inhibitory activities

Fitoterapia. 2014 Mar:93:67-73. doi: 10.1016/j.fitote.2013.11.011. Epub 2013 Dec 7.

Abstract

A new phenylpropanoid glycoside, designated Scrophuside (1) and two new iridoid glycosides, respectively named Ningposide I (2) and Ningposide II (3), along with twelve known (4-15) iridoid and phenylpropanoid glycosides were obtained from the roots of Scrophularia ningpoensis Hemsl. by various chromatographic techniques and their structures were established through chemical methods and spectroscopic analyses. Most of the obtained compounds have been screened for α-Glucosidase inhibitory activity, in which compounds 4, 5, 7, 11, 12, 13, and 14 show significant activity.

Keywords: Iridoid glycosides; Phenylpropanoid glycosides; Scrophularia ningpoensis Hemsl.; Scrophulariaceae; α-Glucosidase inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycoside Hydrolase Inhibitors*
  • Iridoid Glycosides / chemistry
  • Iridoid Glycosides / isolation & purification*
  • Scrophularia / chemistry*
  • alpha-Glucosidases*

Substances

  • Glycoside Hydrolase Inhibitors
  • Iridoid Glycosides
  • ningposide I
  • ningposide II
  • scrophuside
  • alpha-Glucosidases