Improved synthesis and structural reassignment of MC1568: a class IIa selective HDAC inhibitor

J Med Chem. 2014 Feb 13;57(3):1132-5. doi: 10.1021/jm401945k. Epub 2014 Jan 30.

Abstract

An improved synthesis and structural reassignment of the class IIa selective histone deacetylase (HDAC) inhibitor MC1568 are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Histone Deacetylase Inhibitors / chemical synthesis*
  • Histone Deacetylase Inhibitors / chemistry
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Molecular Structure
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry

Substances

  • Histone Deacetylase Inhibitors
  • Hydroxamic Acids
  • MC1568
  • Pyrroles