Molecular aptamer beacon tuned DNA strand displacement to transform small molecules into DNA logic outputs

Jinbo Zhu; Libing Zhang; Zhixue Zhou; Shaojun Dong; Erkang Wang

doi:10.1039/c3cc49833f

Molecular aptamer beacon tuned DNA strand displacement to transform small molecules into DNA logic outputs

Chem Commun (Camb). 2014 Mar 28;50(25):3321-3. doi: 10.1039/c3cc49833f. Epub 2014 Feb 17.

Authors

Jinbo Zhu¹, Libing Zhang, Zhixue Zhou, Shaojun Dong, Erkang Wang

Affiliation

¹ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. ekwang@ciac.jl.cn.

PMID: 24531570
DOI: 10.1039/c3cc49833f

Abstract

A molecular aptamer beacon tuned DNA strand displacement reaction was introduced in this work. This strand displacement mode can be used to transform the adenosine triphosphate (ATP) input into a DNA strand output signal for the downstream gates to process. A simple logic circuit was built on the basis of this mechanism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / chemistry*
Aptamers, Nucleotide / chemistry*
Biosensing Techniques / methods*
DNA / chemistry*
Protoporphyrins / chemistry

Substances

Aptamers, Nucleotide
Protoporphyrins
Adenosine Triphosphate
DNA
protoporphyrin IX