Abstract
Three new macrolactams, heronamides D-F (1-3), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D-F (1-3) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A-C. The relative configurations of 1-3 were deduced by detailed analysis of (3)JHH values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher's method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents
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Bacillus / drug effects
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Candida albicans / drug effects
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Drug Screening Assays, Antitumor
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Escherichia coli / drug effects
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Humans
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Lactams, Macrocyclic / chemistry
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Lactams, Macrocyclic / isolation & purification*
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Lactams, Macrocyclic / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
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Polylysine / chemistry
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Polylysine / isolation & purification*
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Polylysine / pharmacology
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Staphylococcus aureus / drug effects
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Streptomyces / chemistry*
Substances
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Anti-Infective Agents
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Lactams, Macrocyclic
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heronamide D
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heronamide E
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heronamide F
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Polylysine