Abstract
A highly diastereoselective Ru-catalyzed oxidation/reduction sequence of bicyclic methyleneaziridines provides a facile route to complex 1-amino-2,3-diol motifs. The relative anti stereochemistry between the amine and the vicinal alcohol are proposed to result from 1,3-bischelation in the transition state by the C1 and C3 heteroatoms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alcohols / chemical synthesis*
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Alcohols / chemistry
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Aziridines / chemistry*
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Carbamates / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Molecular Structure
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Oxidation-Reduction
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Ruthenium / chemistry
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Stereoisomerism
Substances
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Alcohols
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Aziridines
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Carbamates
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Ruthenium