Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries

J Chromatogr A. 2014 Apr 25:1339:65-72. doi: 10.1016/j.chroma.2014.02.073. Epub 2014 Mar 4.

Abstract

This study describes the identification and evaluation of molecularly imprinted polymers (MIPs) for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals. Screening experiments were performed using existing MIP resin libraries to identify resins selective towards those impurities in the presence of model pharmaceutical compounds. A hit resin with a considerable imprinting effect was found in the screening and upon further investigation, the resin was found to show a broad selectivity towards five different aminopyridines in the presence of the two model active pharmaceutical ingredients (APIs) piroxicam and tenoxicam.

Keywords: Active pharmaceutical ingredients; Aminopyridines; Genotoxic impurities; Molecularly imprinted polymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopyridines / isolation & purification*
  • Carcinogens / isolation & purification*
  • Drug Contamination*
  • Molecular Imprinting
  • Nicotine / analogs & derivatives*
  • Nicotine / chemistry
  • Pharmaceutical Preparations / chemistry*
  • Piroxicam / analogs & derivatives
  • Piroxicam / chemistry
  • Polymers / chemistry*

Substances

  • Aminopyridines
  • Carcinogens
  • Pharmaceutical Preparations
  • Polymers
  • Piroxicam
  • Nicotine
  • nornicotine
  • tenoxicam