Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp

Kei-Ichi Ishidoh; Hiroshi Kinoshita; Yasuhiro Igarashi; Fumio Ihara; Takuya Nihira

doi:10.1038/ja.2014.22

Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp

J Antibiot (Tokyo). 2014 Jun;67(6):459-63. doi: 10.1038/ja.2014.22. Epub 2014 Apr 2.

Authors

Kei-Ichi Ishidoh¹, Hiroshi Kinoshita¹, Yasuhiro Igarashi², Fumio Ihara³, Takuya Nihira⁴

Affiliations

¹ International Center for Biotechnology, Osaka University, Osaka, Japan.
² Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
³ National Institute of Fruit Tree Science, Ibaraki, Japan.
⁴ 1] International Center for Biotechnology, Osaka University, Osaka, Japan [2] Mahidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.

PMID: 24690913
DOI: 10.1038/ja.2014.22

Abstract

Verlamelin and its new derivative (verlamelin B) were isolated from fermentation broth of entomopathogenic fungus Lecanicillium sp. HF627. As the structural elucidation of verlamelin so far was only preliminary, we studied and determined the absolute structure of these two compounds to be cyclo(5S-hydroxytetradecanoic acid-D-alloThr/Ser-D-Ala-L-Pro-L-Gln-D-Tyr-L-Val). This is the first study that precisely analyzed the structure of verlamelin.

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Fermentation
Hypocreales / chemistry*
Peptides, Cyclic / chemistry
Peptides, Cyclic / pharmacology

Substances

Antifungal Agents
Peptides, Cyclic
verlamelin