Microfluidic chip for plasma separation from undiluted human whole blood samples using low voltage contactless dielectrophoresis and capillary force

Lab Chip. 2014 Jun 21;14(12):1996-2001. doi: 10.1039/c4lc00196f. Epub 2014 May 12.

Abstract

A plasma separating biochip is demonstrated using a capillary-driven contactless dielectrophoresis method with low voltage (~1 V) and high frequency induced electrostatics between red blood cells. The polarized red blood cells were aggregated and separated from plasma with a 69.8% volume separation and an 89.4% removal rate of red blood cells.

MeSH terms

  • Electrophoresis, Capillary / instrumentation
  • Electrophoresis, Capillary / methods
  • Humans
  • Microfluidic Analytical Techniques* / instrumentation
  • Microfluidic Analytical Techniques* / methods
  • Plasma*
  • Plasmapheresis* / instrumentation
  • Plasmapheresis* / methods